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Motor Neuron Disease (MND) and Its Causes
by
John Smith
Motor neurons are the nerve cells which send output signals to the muscles, which affect the muscles’ ability to function and slowly the degeneration of organs starts.
It can severely restrict the movement of the patient suffering from Motor Neuron Disease.
The renowned English physicist, Stephen Hawking, has been suffering with the Motor Neuron Disease.
Causes
Motor neurons send signals from the brain to the muscles, the inhibition of these signals lead to Motor Neuron Disease. There are not one but many causes that can probably lead to this horrifying disease.
It does not have singular cause, it can be a mix of various factors forming a very complex cause. Research is being carried out to find the exact cause but here are some of the probable cause of Motor Neuron Disease:
Genetics
Genes play a major role in the culmination of this disease. Genetic mutation is also one of the cause of MND. But contradictory to popular belief, Motor Neuron Disease is not just a genetically oriented disease but it is thought that it is a mixture of both genetics and environmental factors.
Environmental factors
The environment around us is always polluted and releases toxic elements in the atmosphere. The factors that can lead to Motor Neuron Disease, are, chemical release in the atmosphere and exposure to it, and excessive smoking.
Strenuous work
Excessive amount of strenuous exercise or doing jobs which involve bodily struggle like being a sports person, an athlete or doing military service can also be the cause of the Motor Neuron Disease.
Abnormal Mitochondria
Mitochondria are called the power house of the cell as it supplies power and energy to the cell. The mitochondrion in each is collectively responsible for providing energy to the energy for the functioning of the cells, but they tend behave abnormally and lead Motor Neuron Disease.
Neurotransmitters
Neurotransmitters are chemical substance in the body to help in transmitting nerve signals. One of the neurotransmitter is glutamate, which the cells get sensitive to, rupturing of the cells.
Nutrient Cells
Motor neurons are surrounded by cells which provide nutrients to it, these cells are called Glial cells. In MND, the glial cells inhibit support and provision of nutrients to the motor neurons.
Cell transport
The cell transport system gets disrupted in Motor Neuron Diseases. The cell transports which involves bring nutrients and other chemicals inside the cell getting rid of toxic substance. When the disruption of the cell takes place, the smooth transition of the transport system gets disturbed.
Abnormal Protein
Clumps of abnormal protein called the Aggregate disrupt the normal working of the motor neurons causing Motor Neuron Disease.
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